In today’s fast-paced world, achieving and maintaining health requires more than just treating symptoms-it demands a holistic approach that honors the interconnectedness of body, mind, and spirit. At Inquire Within™ Behavioral Health, we believe that optimal well-being starts with vital nutrient balance. This post explores the essential lab work for identifying deficiencies, the role of medication, supplements, herbal remedies, brain-nourishing foods, therapy, and the importance of sleep and exercise in building resilience. If you or a loved one identify with symptoms of imbalance or stress, contact us now to begin your journey to holistic health.
Nutrient balance is the cornerstone of holistic health, influencing physical vitality, mental clarity, and emotional stability. Every cell in your body relies on a steady supply of vitamins, minerals, amino acids, and healthy fats to function optimally. When these nutrients are out of balance, you may experience fatigue, mood swings, brain fog, weakened immunity, and reduced resilience to stress. Research confirms that nutrition impacts brain chemistry, neuroplasticity, inflammation, and the gut-brain axis, all of which are critical for mental health (Godos et al., 2021; Ortega et al., 2022).
Understanding your unique nutrient status is the first step toward targeted, effective wellness. Comprehensive lab panels can uncover hidden deficiencies that may be undermining your health and resilience:
Nutritional Deficiency Discovery Panel: Tests for iron, ferritin, vitamin B12, folate, vitamin D, magnesium, zinc, copper, selenium, and more. These markers help identify issues like anemia, immune dysfunction, neurological symptoms, and metabolic disturbances (Ulta Lab Tests, n.d.).
Comprehensive Metabolic Panel (CMP): Assesses kidney and liver function, electrolyte balance, and blood sugar regulation-all crucial for overall health.
Thyroid Function Tests: Thyroid hormones influence metabolism, energy, and mood.
Inflammatory Markers (CRP, ESR): Chronic inflammation can signal underlying nutrient imbalances or stress.
Gut Health Panels: Evaluate microbiome diversity, digestive function, and absorption of nutrients.
Regular lab work empowers you and your provider to create a personalized plan that addresses the root causes of symptoms, rather than just masking them.
A growing body of research confirms that nutrition plays a fundamental role in mental health, impacting brain chemistry, neuroplasticity, inflammation, and the gut-brain axis. Below, we expand on how key nutrients-including each of the B vitamins-contribute to psychological resilience and emotional well-being.
B vitamins are water-soluble nutrients that act as coenzymes in numerous metabolic processes vital for brain health. Each B vitamin has unique, research-backed roles in supporting mental health and resilience (Animo Sano Psychiatry, 2023):
Vitamin B1 (Thiamine):
Crucial for energy metabolism in the brain and supports nerve function. Deficiency can lead to irritability, depression, and cognitive dysfunction.
Vitamin B2 (Riboflavin):
Helps extract energy from carbohydrates, fats, and proteins and is vital for cellular growth and function. Riboflavin deficiency has been linked to mood disturbances and migraines.
Vitamin B3 (Niacin):
Necessary for the synthesis of NAD and NADP, coenzymes involved in energy production and DNA repair. Deficiency can lead to depression, apathy, and memory loss.
Vitamin B5 (Pantothenic Acid):
Essential for synthesizing coenzyme A, critical for fatty acid metabolism and the production of neurotransmitters. Low levels may contribute to fatigue, irritability, and mood disturbances.
Vitamin B6 (Pyridoxine):
Vital for the conversion of tryptophan to serotonin, a neurotransmitter that regulates mood. Deficiency is associated with increased risk of depression and anxiety. High-dose B6 supplementation can reduce symptoms of anxiety and depression by enhancing GABA production (Field et al., 2022).
Vitamin B7 (Biotin):
Supports fatty acid synthesis and energy production, important for nervous system health. Deficiency can cause neurological symptoms such as depression and lethargy.
Vitamin B9 (Folate/Folic Acid):
Involved in DNA synthesis, repair, and methylation, as well as the production of neurotransmitters like serotonin and dopamine. Low folate levels are consistently linked to depression, cognitive decline, and poor response to antidepressant therapy. Supplementation, especially with L-methylfolate, can enhance the effectiveness of antidepressant medications (Dr. Shier, 2017).
Vitamin B12 (Cobalamin):
Crucial for the formation and maintenance of the myelin sheath (which protects nerve fibers) and for the synthesis of neurotransmitters. Deficiency can cause depression, cognitive impairment, and memory loss. Supplementation has been shown to improve mood and augment antidepressant response.
Omega-3 Fatty Acids (EPA & DHA):
Integral to brain cell membrane structure and function, reduce neuroinflammation, and support neurotransmitter signaling. Adequate intake is associated with lower rates of depression and improved cognitive function (Godos et al., 2021).
Magnesium:
Regulates the HPA axis (the body’s stress response system), supports neurotransmitter function, and has anti-inflammatory properties. Deficiency is linked to increased risk of depression, anxiety, and sleep disturbances.
Vitamin D:
Vitamin D receptors are present in brain regions involved in mood regulation. Deficiency is associated with increased risk of depression and cognitive impairment. Supplementation may improve mood, especially in those with low baseline levels.
Zinc:
Involved in neurotransmitter function and neurogenesis. Low zinc levels are associated with depression and impaired cognitive function.
Iron:
Essential for oxygen transport and neurotransmitter synthesis. Deficiency can cause fatigue, brain fog, and mood disturbances.
While nutrition is foundational, medication can play a vital role in stabilizing mood, supporting brain chemistry, and building resilience-especially when deficiencies contribute to mental health challenges. Medications such as antidepressants and mood stabilizers work by balancing neurotransmitters, which are dependent on adequate nutrient levels to function properly.
A “resilient prescribing” approach emphasizes patient empowerment, education, and collaboration. Medication is most effective when individuals understand its role, maintain self-efficacy, and combine it with lifestyle changes and therapy. Consistent medication adherence can stabilize mood, prevent relapses, and enhance daily functioning, providing a stable platform for further growth (Mount Sinai, 2018).
Emerging research also explores medications that directly enhance psychological resilience, potentially reducing the risk of depression and stress-related disorders by modulating brain circuits involved in adaptation.
When lab work reveals deficiencies or when added support is needed, supplements and herbal remedies can bridge the gap:
Magnesium: Supports nerve function, muscle relaxation, and stress resilience.
Vitamin D: Essential for immune function, mood regulation, and bone health.
B Vitamins (B6, B12, Folate): Crucial for energy, neurotransmitter synthesis, and cognitive function.
Omega-3 Fatty Acids: Reduce inflammation, support brain health, and enhance mood.
Ashwagandha: An adaptogen that reduces cortisol, improves mood, and enhances resilience to stress.
Rhodiola: Eases fatigue, improves recovery from stress, and supports mental performance.
St. John’s Wort: Effective for mild to moderate depression, boosts neurotransmitters, and improves sleep.
Motherwort, Linden, Albizia: Soothe anxiety, support emotional well-being, and promote restful sleep.
These natural remedies work best when tailored to individual needs and combined with professional guidance to ensure safety and efficacy (PMC, 2022).
Food is medicine. A nutrient-rich, whole-foods diet provides the building blocks for resilience at every level (Harvard Health Publishing, 2024):
Leafy Greens (Spinach, Kale, Broccoli): Packed with vitamins K, C, E, and folate, these support cognitive function and reduce inflammation.
Fatty Fish (Salmon, Sardines): Rich in omega-3s, which are vital for brain health and mood regulation.
Eggs: Provide choline, B vitamins, and healthy fats for neurotransmitter production and memory.
Berries: Loaded with antioxidants that protect the brain and enhance memory.
Nuts and Seeds (Cashews, Walnuts, Pumpkin Seeds): Offer magnesium, zinc, and healthy fats for brain resilience.
Fermented Foods (Yogurt, Sauerkraut, Kimchi): Support gut health, which is closely linked to mood and cognition.
Sweet Potatoes, Avocado, Dark Chocolate: Supply vitamins, fiber, and polyphenols that reduce stress and support overall well-being.
Mindful eating-paying attention to hunger, fullness, and the sensory experience of food-can further improve digestion and satisfaction.
Therapy is a powerful tool for cultivating resilience, teaching active coping skills, and enhancing self-awareness. Evidence-based approaches include:
Cognitive Behavioral Therapy (CBT): Helps reframe negative thoughts, build problem-solving skills, and foster adaptive coping.
Mindfulness and Meditation: Reduce stress, improve emotional regulation, and enhance present-moment awareness.
Behavioral Activation: Encourages engagement in meaningful activities, counteracting apathy and learned helplessness.
Holistic Therapies (Yoga, Acupuncture): Integrate mind and body, reduce tension, and support emotional healing.
Therapy is most effective when integrated with lifestyle changes, nutrition, and, if needed, medication-creating a comprehensive plan for lasting well-being (PMC, 2019; Indiana Center for Recovery, 2025).
True resilience is built on a foundation of restorative sleep and regular movement:
Sleep Hygiene: Quality sleep is essential for cognitive function, emotional regulation, and physical repair. Aim for 7–9 hours per night, maintain a consistent schedule, and create a calming bedtime routine.
Exercise: Regular physical activity reduces stress, improves sleep quality, boosts mood, and supports overall health. Both aerobic and resistance training are beneficial; even moderate daily movement can enhance resilience and well-being (Nature, 2025).
Diet, exercise, and sleep are deeply interconnected-prioritizing all three is key to maintaining health and preventing burnout.
At Inquire Within™ Behavioral Health, we believe that health is more than the absence of disease-it’s a dynamic state of balance, vitality, and resilience. By combining lab-based insights, targeted medication, supplements, nourishing foods, therapy, and lifestyle practices, we empower you to thrive in body, mind, and spirit.
If you or a loved one identify with symptoms of nutrient imbalance, fatigue, mood changes, or chronic stress, contact us now to start your journey toward holistic health.
Animo Sano Psychiatry. (2023, June 1). The role of vitamin B group in mental health. https://animosanopsychiatry.com/the-role-of-vitamin-b-group-in-mental-health/
Dr. Shier. (2017, October 5). Mental health benefits of folic acid and vitamin B12. https://www.drshier.com/mental-health-benefits-folic-acid-vitamin-b12/
Field, D., et al. (2022, November 11). Vitamin B6 supplements reduces anxiety, depression in new study. Pharmacy Times. https://www.pharmacytimes.com/view/vitamin-b6-supplements-reduces-anxiety-depression-in-new-study
Godos, J., et al. (2021, March 8). The impact of nutrients on mental health and well-being. Frontiers in Nutrition, 8, 685. https://pmc.ncbi.nlm.nih.gov/articles/PMC7982519/
Harvard Health Publishing. (2024, April 3). Foods linked to better brainpower. https://www.health.harvard.edu/healthbeat/foods-linked-to-better-brainpower
Indiana Center for Recovery. (2025, January 27). Holistic therapy for emotional and mental health. https://www.treatmentindiana.com/resources/mental-health/holistic-therapy-for-emotional-and-mental-health/
Mount Sinai. (2018, April 11). Can a pill that boosts “resilience” treat depression? https://www.mountsinai.org/about/newsroom/2018/can-a-pill-that-boosts-resilience-treat-depression-gary-stix
Nature. (2025, February 3). The impact of exercise on sleep and sleep disorders. https://www.nature.com/articles/s44323-024-00018-w
Ortega, M. A., et al. (2022, August 22). Nutrition and mental health: A review of current knowledge about the impact of diet on mental health. Frontiers in Nutrition, 9, 889. https://pmc.ncbi.nlm.nih.gov/articles/PMC9441951/
PMC. (2019, September 9). Building resilience through psychotherapy. https://pmc.ncbi.nlm.nih.gov/articles/PMC6732704/
PMC. (2022, December 10). The science and strategy of a botanical medicine approach to self-care. https://pmc.ncbi.nlm.nih.gov/articles/PMC9737923/
Ulta Lab Tests. (n.d.). Nutritional deficiency discovery panel. https://www.ultalabtests.com/test/nutritional-deficiency-discovery-panel
Willingness. (2023, September 6). 10 nutritional foods that build mental resilience. https://www.willingness.com.mt/10-nutritional-foods-that-build-mental-resilience/
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